Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

@article{Lai2008TranscriptionalCP,
  title={Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.},
  author={Ling Lai and T. Leone and C. Zechner and P. Schaeffer and S. Kelly and Daniel P Flanagan and D. Medeiros and A. Kov{\'a}cs and D. Kelly},
  journal={Genes \& development},
  year={2008},
  volume={22 14},
  pages={
          1948-61
        }
}
Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARgamma coactivator-1 (PGC-1) alpha and beta have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1alpha and PGC-1beta (PGC-1alphabeta(-/-) mice) were generated to investigate the convergence of their functions in vivo. The phenotype of PGC-1beta(-/-) mice was minimal under nonstressed conditions… Expand
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