Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

@article{Kim2015TranscriptionalCF,
  title={Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.},
  author={Minchul Kim and Taekhoon Kim and Randy L. Johnson and Dae-Sik Lim},
  journal={Cell reports},
  year={2015},
  volume={11 2},
  pages={270-82}
}
YAP (yes-associated protein) and TAZ are oncogenic transcriptional co-activators downstream of the Hippo tumor-suppressor pathway. However, whether YAP and/or TAZ (YAP/TAZ) engage in transcriptional co-repression remains relatively unexplored. Here, we directly demonstrated that YAP/TAZ represses numerous target genes, including tumor-suppressor genes such as DDIT4 (DNA-damage-inducible transcript 4) and Trail (TNF-related apoptosis-inducing ligand). Mechanistically, the repressor function of… CONTINUE READING
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