Transcriptional changes that characterize the immune reactions of leprosy.

  title={Transcriptional changes that characterize the immune reactions of leprosy.},
  author={Kathryn Dupnik and Thomas B. Bair and Andressa O Maia and Francianne M. Amorim and Marcos Romualdo Costa and T S L Keesen and Joanna Gardel Valverde and Maria do Carmo Ara{\'u}jo Palmeira Queiroz and L{\'u}cio L Medeiros and Nelly L de Lucena and Mary E Wilson and Mauricio Lisboa Nobre and Warren D. Johnson and Selma M B Jeronimo},
  journal={The Journal of infectious diseases},
  volume={211 10},
BACKGROUND Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL). METHODS To discover host factors related to immune reactions, global transcriptional profiles of peripheral blood mononuclear cells were compared between 11 RR, 11 ENL, and 19 matched control patients, with confirmation by quantitative polymerase chain reaction. Encoded proteins were investigated in skin biopsy specimens by means of immunohistochemistry… CONTINUE READING


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