Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis.


Cell-cell junctions and junctions between cells and extracellular matrix are essential for maintenance of the structural and functional integrity of the cochlea, and are also a major target of acoustic trauma. While morphological assessments have revealed adhesion dysfunction in noise-traumatized cochleae, the molecular mechanisms responsible for adhesion… (More)
DOI: 10.1016/j.nbd.2011.10.018

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