Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized

@article{Li2006TranscriptionalCA,
  title={Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized},
  author={Yizheng Li and Jing Pan and Jian-liang Li and Jee Hyung Lee and Chris Tunkey and Kathryn A Saraf and James C. Garbe and Maryann Z Whitley and Scott A Jelinsky and Martha R. Stampfer and Steven A. Haney},
  journal={Molecular Cancer},
  year={2006},
  volume={6},
  pages={7 - 7}
}
Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome an Rb-mediated stress-associated senescence barrier (stasis), and a stringent, telomere-length dependent, barrier (agonescence or crisis, depending on p53 status). HMEC that have overcome the second senescence barrier are immortalized. We have characterized pre-stasis, post-selection… CONTINUE READING
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