Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation field.

@article{Chauhan2016TranscriptionalBD,
  title={Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation field.},
  author={Vinita Chauhan and Byron Kuo and J. P. Mcnamee and Ruth C Wilkins and Carole L. Yauk},
  journal={Environmental and molecular mutagenesis},
  year={2016},
  volume={57 8},
  pages={
          589-604
        }
}
Recent advances in "-omics" technologies have simplified capacity to concurrently assess expression profiles of thousands of targets in a cellular system. However, compilation and analysis of "omics" data in support of human health protection remains a challenge. Benchmark dose (BMD) modeling is currently being employed in chemical risk assessment to estimate acceptable levels of exposure. Although typically applied to conventional endpoints, newer software has enabled this application to be… CONTINUE READING
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