Transcriptional basis of lymphocyte tolerance.

  title={Transcriptional basis of lymphocyte tolerance.},
  author={Madhuri Borde and Robert A Barrington and Vigo Heissmeyer and Michael C Carroll and Anjana Rao},
  journal={Immunological reviews},
Signaling through lymphocyte antigen receptors has the potential to initiate several distinct outcomes: proliferation, differentiation, apoptosis, or functional unresponsiveness. Expansion and differentiation of effector T cells is required for defense against foreign antigens, whereas functional unresponsiveness, termed anergy, is a cell-intrinsic mechanism that contributes to peripheral self-tolerance. Other mechanisms of peripheral tolerance include the 'dominant' tolerance imposed by… CONTINUE READING


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