Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.

@article{Hollander2015TranscriptionalAO,
  title={Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage.},
  author={Wouter den Hollander and Yolande F M Ramos and Nils Bomer and Stefan Elzinga and Ruud van der Breggen and N. Lakenberg and Wesley J de Dijcker and H Eka D Suchiman and Bouke J Duijnisveld and Jeanine J. Houwing-Duistermaat and Pieternella E Slagboom and S D Bos and Rob G. H. H. Nelissen and Ingrid Meulenbelt},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 8},
  pages={2108-16}
}
OBJECTIVE To identify osteoarthritis (OA) progression-modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic determinants in end-stage disease. METHODS Transcriptional activity of CpG was assessed using gene expression data and DNA methylation data for preserved and lesional articular cartilage samples. Disease… CONTINUE READING