Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.

@article{Jin2013TranscriptionalAT,
  title={Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.},
  author={Jingling Jin and Polina A Iakova and Yan-Jun Jiang and Kyle Joseph Edward Lewis and Emily M Sullivan and Nicole Jawanmardi and Lawrence A. Donehower and Lubov Timchenko and Nikolai A. Timchenko},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 20},
  pages={14451-62}
}
Cancer changes biological processes in the liver by altering gene expression at the levels of transcription, translation, and protein modification. The RNA binding protein CUGBP1 is a key regulator of translation of CCAAT enhancer binding protein β and histone deacetylase 1 (HDAC1). These proteins form complexes that are involved in the regulation of liver biology. Here we show a critical role of the translational activation of CCAAT/enhancer binding protein β-HDAC1 complexes in the development… CONTINUE READING
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