Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?

@article{Hou2008TranscriptionalAS,
  title={Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?},
  author={Ling Hou and William J. Pavan},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={1163-1176}
}
Human neurocristopathies include a number of syndromes, tumors, and dysmorphologies of neural crest (NC) stem cell derivatives. In recent years, many white spotting genes have been associated with hypopigmentary disorders and deafness in neurocristopathies resulting from NC stem cell-derived melanocyte deficiency during development. These include PAX3, SOX10, MITF, SNAI2, EDNRB, EDN3, KIT, and KITL. Recent studies have revealed surprising new insights into a central role of MITF in the complex… CONTINUE READING

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