Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells.

@article{Phelps2006TranscriptionalAP,
  title={Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells.},
  author={Eric D Phelps and Dawn L Updike and Elizabeth C. Bullen and Paula Grammas and Eric W. Howard},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={290 2},
  pages={C352-61}
}
Angiopoietins play a significant role in vascular development and angiogenesis. Both angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) bind the receptor tyrosine kinase Tie2. However, while Ang1 signaling results in the stabilization of vessel structure, Ang2 has been linked to vascular instability. The ratio of these two Tie2 ligands is thus critical for vascular stability and remodeling. This study identifies a mechanism of growth factor-mediated reduction in Ang2 expression in vascular smooth… CONTINUE READING

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