Transcriptional and posttranscriptional regulation of HIV-1 gene expression.

  title={Transcriptional and posttranscriptional regulation of HIV-1 gene expression.},
  author={Jonathan Karn and C. Martin Stoltzfus},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={2 2},
Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat stimulates transcription elongation by directing the cellular transcriptional elongation factor P-TEFb to nascent RNA polymerases. Rev is required for the transport from the nucleus to the cytoplasm of the unspliced and incompletely spliced mRNAs that encode the structural proteins of the virus. Molecular studies of both proteins have revealed how they interact with the cellular machinery to control… CONTINUE READING
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