Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53

@inproceedings{Narayanan2017TranscriptionalAP,
  title={Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53},
  author={Ishwarya Venkata Narayanan and Michelle T. Paulsen and K Bedi and Nathan Berg and Emily A. Ljungman and Sofia Francia and Artur Botelho Veloso and Brian Magnuson and Fabrizio d’Adda di Fagagna and Thomas E Wilson and Mats Ljungman},
  booktitle={Scientific reports},
  year={2017}
}
In response to ionizing radiation (IR), cells activate a DNA damage response (DDR) pathway to re-program gene expression. Previous studies using total cellular RNA analyses have shown that the stress kinase ATM and the transcription factor p53 are integral components required for induction of IR-induced gene expression. These studies did not distinguish between changes in RNA synthesis and RNA turnover and did not address the role of enhancer elements in DDR-mediated transcriptional regulation… CONTINUE READING

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