Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage.

@article{Biswas2012TranscriptionalAN,
  title={Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage.},
  author={Anup Biswas and D. B. Johnson},
  journal={Cancer research},
  year={2012},
  volume={72 1},
  pages={13-7}
}
E2F is a family of transcription factors that regulate the expression of genes involved in a wide range of cellular processes, including cell-cycle progression, DNA replication, DNA repair, differentiation, and apoptosis. E2F1, the founding member of the family, undergoes posttranslational modifications in response to DNA damage, resulting in E2F1 stabilization. In some cases, E2F1 is important for DNA damage-induced apoptosis through the transcriptional activation of p73 and perhaps other… CONTINUE READING
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