Transcriptional and metabolomic consequences of LuxS inactivation reveal a metabolic rather than quorum-sensing role for LuxS in Lactobacillus reuteri 100-23.

@article{Wilson2012TranscriptionalAM,
  title={Transcriptional and metabolomic consequences of LuxS inactivation reveal a metabolic rather than quorum-sensing role for LuxS in Lactobacillus reuteri 100-23.},
  author={Charlotte M. Wilson and Raphael B. M. Aggio and Paul W O'Toole and Silas Granato Villas-B{\^o}as and Gerald W. Tannock},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 7},
  pages={1743-6}
}
Autoinducer-2 (AI-2)-mediated quorum sensing has been extensively studied in relation to the regulation of microbial behavior. There are, however, two potential roles for the AI-2 synthase (LuxS). The first is in the production of AI-2 and the second is as an enzyme in the activated methyl cycle, where it catalyzes the conversion of S-ribosylhomocysteine to homocysteine. The by-product of the reaction catalyzed by LuxS is (S)-4,5-dihydroxy-2,3-pentanedione, which spontaneously forms the… CONTINUE READING

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