Transcriptional and Translational Regulation of Stem Cells

  title={Transcriptional and Translational Regulation of Stem Cells},
  author={Gary R Hime and Helen Abud},
  booktitle={Advances in Experimental Medicine and Biology},
This volume describes the latest fi ndings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 10 times. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 317 references

De novo generation of neuronal cells from the adult mouse brain.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 9 Excerpts
Highly Influenced

Developmental Origin of Neural Stem Cells: The Glial Cell That Could

Stem Cell Reviews and Reports • 2012
View 3 Excerpts
Highly Influenced

Transcription factors and neural stem cell self-renewal, growth and differentiation.

Cell adhesion & migration • 2009
View 3 Excerpts
Highly Influenced

A critical cell-intrinsic role for serum response factor in glial specification in the CNS.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2

C Andreu-Agullo

Similar Papers

Loading similar papers…