Transcriptional and Posttranscriptional Regulations of the HLA-G Gene

@inproceedings{Castelli2014TranscriptionalAP,
  title={Transcriptional and Posttranscriptional Regulations of the HLA-G Gene},
  author={Erick C Castelli and Luciana Caricati Veiga-Castelli and Layale Yaghi and Philippe Moreau and Eduardo Ant{\^o}nio Donadi},
  booktitle={Journal of immunology research},
  year={2014}
}
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-γ and NF-κB, (ii) the proximal promoter region (within 200 bases… CONTINUE READING

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