Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori.

@article{Spohn1997TranscriptionalAO,
  title={Transcriptional analysis of the divergent cagAB genes encoded by the pathogenicity island of Helicobacter pylori.},
  author={Gunther Spohn and Dagmar Beier and Rino Rappuoli and Vincenzo Scarlato},
  journal={Molecular microbiology},
  year={1997},
  volume={26 2},
  pages={
          361-72
        }
}
Helicobacter pylori strains isolated from most patients with peptic ulcer disease and adenocarcinoma express the vacuolating toxin VacA and contain a pathogenicity island named cag. The cag pathogenicity island codes for more than 40 putative proteins with features similar to bacterial secretion systems. One of these proteins, CagA, is an immunodominant antigen with unknown function encoded by the cagA gene. In the present study, we have analysed the functional promoter elements of the H… CONTINUE READING
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