Transcriptional analysis of the EhPgp1 promoter of Entamoeba histolytica multidrug-resistant mutant.

@article{Gomez1998TranscriptionalAO,
  title={Transcriptional analysis of the EhPgp1 promoter of Entamoeba histolytica multidrug-resistant mutant.},
  author={Carolina B Gomez and D. Guillermo P{\'e}rez and Esther L{\'o}pez-Bayghen and Esther Orozco},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 13},
  pages={7277-84}
}
We present here the cloning and characterization of the EhPgp1 multidrug resistance gene promoter isolated from the Entamoeba histolytica drug-resistant mutant clone C2. The EhPgp1 promoter lacks the typical TATA box and the transcriptional initiation sequences described for other E. histolytica promoters. The major transcription initiation site of the EhPgp1 gene was located at the ATG start codon. The EhPgp1 core promoter located within the first 244 base pairs showed a higher chloramphenicol… CONTINUE READING

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