Transcriptional analysis of left-sided colitis, pancolitis, and ulcerative colitis-associated dysplasia.

  title={Transcriptional analysis of left-sided colitis, pancolitis, and ulcerative colitis-associated dysplasia.},
  author={Jacob Tveiten Bjerrum and Ole Haagen Nielsen and Lene Buhl Riis and Val{\'e}rie Pittet and Christoph M{\"u}ller and Gerhard Rogler and J\orgen Olsen},
  journal={Inflammatory bowel diseases},
  volume={20 12},
BACKGROUND It is unknown why patients with extensive ulcerative colitis (UC) have a higher risk of colorectal cancer compared with patients with left-sided UC. This study characterizes the inflammatory processes in left-sided UC, pancolitis, and UC-associated dysplasia at the transcriptional level to identify potential biomarkers and transcripts of importance for the carcinogenic behavior of chronic inflammation. METHODS The Affymetrix GeneChip Human Genome U133 Plus 2.0 was applied on… CONTINUE READING
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