Transcriptional analysis of early lineage commitment in human embryonic stem cells

  title={Transcriptional analysis of early lineage commitment in human embryonic stem cells},
  author={Andrew L Laslett and Sean M. Grimmond and Brooke B A Gardiner and Lincon A Stamp and Adelia Lin and Susan M. Hawes and Samuel Wormald and David J Nikolic-Paterson and David N. Haylock and Martin F Pera},
  journal={BMC Developmental Biology},
  pages={12 - 12}
The mechanisms responsible for the maintenance of pluripotency in human embryonic stem cells, and those that drive their commitment into particular differentiation lineages, are poorly understood. In fact, even our knowledge of the phenotype of hESC is limited, because the immunological and molecular criteria presently used to define this phenotype describe the properties of a heterogeneous population of cells. We used a novel approach combining immunological and transcriptional analysis… CONTINUE READING
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