Transcriptional activator TonE-binding protein in cellular protection and differentiation.


The TonE-binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFkappaB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammation. Established methods for biochemical and histochemical detection and functional analysis of TonEBP, including identification of novel TonEBP target genes, are described for those who are interested in investigating function and regulation of TonEBP.

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@article{Kim2007TranscriptionalAT, title={Transcriptional activator TonE-binding protein in cellular protection and differentiation.}, author={Jeong Ah Kim and Un Sil Jeon and Min Seong Kwon and Sun Woo Lim and Hyug Moo Kwon}, journal={Methods in enzymology}, year={2007}, volume={428}, pages={253-67} }