Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105.

@article{Hirai1992TranscriptionalAT,
  title={Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105.},
  author={Hirohisa Hirai and Jun-ichi Fujisawa and Takeshi Suzuki and Kunihiro Ueda and Mikiko Muramatsu and Akio Tsuboi and Naoya Arai and Mitsuaki Yoshida},
  journal={Oncogene},
  year={1992},
  volume={7 9},
  pages={1737-42}
}
Human T-cell leukemia virus type 1 (HTLV-1) induces adult T-cell leukemia and also a neurological disease, tropical spastic paraparesis. Tax protein (p40tax) of HTLV-1 activates in trans its own transcriptional enhancer in the long terminal repeat and also those in some cellular genes such as interleukin 2 receptor alpha, granulocyte-macrophage colony-stimulating factor, Fos, Jun and MHC class I. Thus, Tax has been proposed to play a critical role in the pathogenesis induced by HTLV-1 infection… CONTINUE READING
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