Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs.


The active form of vitamin D3 (1α,25(OH)2D3, also known as calcitriol) controls the expression of target genes via the vitamin D receptor (VDR). Vitamin D-dependent rickets type II (VDDRII) is a congenital disease caused by inactivating mutations in the VDR The condition is treated with high doses of calcitriol, but the therapeutic effects of other… (More)
DOI: 10.1530/JME-16-0048