Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site

@inproceedings{Kirschner2008TranscriptionalAO,
  title={Transcriptional activation of the tumor suppressor and differentiation gene S100A2 by a novel p63-binding site},
  author={Ralf D. Kirschner and Katja S{\"a}nger and Gerd A M{\"u}ller and Kurt Engeland},
  booktitle={Nucleic acids research},
  year={2008}
}
S100A2 is generally found expressed in the epidermis and was recently shown to play a crucial role in the differentiation of keratinocytes. Also known as CaN19, S100A2 was identified as a potential tumor suppressor. Expression of S100A2 is upregulated by p53. The proteins p63 and p73 are related to p53 and are expressed as several splice variants with partially overlapping tasks but also functions different from p53. It had been shown that p63 proteins with mutations in their DNA-binding domain… CONTINUE READING