Transcriptional activation of the alpha 1(VI) collagen gene during myoblast differentiation is mediated by multiple GA boxes.

@article{Piccolo1995TranscriptionalAO,
  title={Transcriptional activation of the alpha 1(VI) collagen gene during myoblast differentiation is mediated by multiple GA boxes.},
  author={Stefano Piccolo and Paolo Bonaldo and Paola Vitale and Dino Volpin and Giorgio Maria Bressan},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 33},
  pages={19583-90}
}
During differentiation of ClC12 myoblasts in vitro, expression of alpha 1(VI) collagen mRNA was transiently stimulated severalfold. Promoter assays on cells transfected with chloramphenicol acetyltransferase (CAT) chimeric constructs have identified a region of the alpha 1(VI) a collagen promoter that increases CAT activity about 8-fold during differentiation. The region, which overlaps with transcription initiation sites, was shown to contain three protected segments (A, B, and C) in DNase I… CONTINUE READING