Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.

@article{Robertson1995TranscriptionalAO,
  title={Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.},
  author={Keith D. Robertson and Stephen D. Hayward and Paul D. Ling and Dvorit Samid and Richard Frederick Ambinder},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15 11},
  pages={
          6150-9
        }
}
The Epstein-Barr Virus (EBV) latency C promoter (Cp) is the origin of transcripts for six viral proteins. The promoter is active in lymphoblastoid B-cell lines but silent in many EBV-associated tumors and tumor cell lines. In these latter cell lines, the viral episome is hypermethylated in the vicinity of this promoter. We show that in such a cell line (Rael, a Burkitt's lymphoma line), 5-azacytidine inhibits DNA methyltransferase, brings about demethylation of EBV genomes, activates Cp… CONTINUE READING
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