Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16.

@article{Desaintes1992TranscriptionalAO,
  title={Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16.},
  author={Christian Desaintes and Sophie Hallez and Petra van Alphen and Ars{\`e}ne Burny},
  journal={Journal of virology},
  year={1992},
  volume={66 1},
  pages={
          325-33
        }
}
The E6 protein of human papillomavirus type 16 (HPV-16), along with E7, is responsible for the HPV-induced malignant transformation of the cervix. However, the mechanism of this transformation activity is not well understood. We investigated whether the entire E6 protein of HPV-16 could act as an activator of transcription. Experiments in which NIH 3T3 cells were cotransfected with an E6 expression vector together with the reporter chloramphenicol acetyltransferase (CAT) gene linked to various… CONTINUE READING
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