Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2.

@article{Kubota1999TranscriptionalAO,
  title={Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2.},
  author={Hiroshi Kubota and Seiji Matsumoto and Shuichiro Yokota and Hideki Yanagi and Takashi Yura},
  journal={FEBS letters},
  year={1999},
  volume={461 1-2},
  pages={
          125-9
        }
}
The chaperonin containing TCP-1 (CCT) is a eukaryotic molecular chaperone consisting of eight subunit species and assists in the folding of cytosolic proteins. We show here that all eight mouse CCT subunit genes contain sequences called heat shock elements for binding heat shock transcription factors (HSFs) by electrophoretic mobility shift assays and that these genes are transcriptionally activated by HSFs in reporter gene assays using HeLa cells transiently overexpressing HSFs. These results… CONTINUE READING
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