Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.

  title={Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.},
  author={Nina Raver-Shapira and Efi Marciano and Eti Meiri and Yael Spector and Nitzan Rosenfeld and Neta Moskovits and Zvi Bentwich and Moshe Oren},
  journal={Molecular cell},
  volume={26 5},
p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator. Here we report that, in addition to regulating the expression of hundreds of protein-coding genes, p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a. Processing of… CONTINUE READING
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