Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.

@article{RaverShapira2007TranscriptionalAO,
  title={Transcriptional activation of miR-34a contributes to p53-mediated apoptosis.},
  author={Nina Raver-Shapira and Efi Marciano and Eti Meiri and Yael Spector and Nitzan Rosenfeld and Neta Moskovits and Zvi Bentwich and Moshe Oren},
  journal={Molecular cell},
  year={2007},
  volume={26 5},
  pages={731-43}
}
p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator. Here we report that, in addition to regulating the expression of hundreds of protein-coding genes, p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a. Processing of… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
489 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 489 extracted citations

Similar Papers

Loading similar papers…