Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.

@article{Rajpal2003TranscriptionalAO,
  title={Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor.},
  author={Arvind Rajpal and Yuri A Cho and Biana Yelent and P. Koza-Taylor and Dongling Li and Elaine T. Chen and Michael Whang and Chulho Kang and Thomas G. Turi and Astar Winoto},
  journal={The EMBO journal},
  year={2003},
  volume={22 24},
  pages={6526-36}
}
Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear. In some cell lines, Nur77 was reported to act through a transcription-independent mechanism involving translocation to mitochondria, leading to cytochrome c release. However, we show here that Nur77-mediated apoptosis in thymocytes does not involve cytoplasmic cytochrome c release and cannot be… CONTINUE READING

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