Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8.

@article{Ahn2014TranscriptionalAO,
  title={Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8.},
  author={G-One Ahn and Jun Seita and Beom-Ju Hong and Y. R. Kim and Seoyeon Bok and Chan-Ju Lee and Kwang Soon Kim and Jerry C Lee and Nicholas J. Leeper and John P Cooke and Hak Jae Kim and Il Han Kim and Irving L Weissman and J. Martin Brown},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 7},
  pages={2698-703}
}
Emerging evidence indicates that myeloid cells are essential for promoting new blood vessel formation by secreting various angiogenic factors. Given that hypoxia-inducible factor (HIF) is a critical regulator for angiogenesis, we questioned whether HIF in myeloid cells also plays a role in promoting angiogenesis. To address this question, we generated a unique strain of myeloid-specific knockout mice targeting HIF pathways using human S100A8 as a myeloid-specific promoter. We observed that… CONTINUE READING