Transcriptional activation of c-myc proto-oncogene by WT1 protein


The Wilms’ tumor 1 gene (WT1) plays an essential role in urogenital development and malignancy. Through DNA binding, WT1 can either enhance or repress transcription depending on the context of the DNA-binding sites or the cell type in which it is expressed. WT1 is overexpressed in a variety of human cancers, including leukemia and breast cancer; in these… (More)
DOI: 10.1038/sj.onc.1207609

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