Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).

@article{Bahat2015TranscriptionalAO,
  title={Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR).},
  author={Assaf Bahat and Shira Perlberg and Naomi Melamed-Book and S. Suthakar Isaac and Amir Eden and Ines Lauria and Thomas Langer and Joseph Orly},
  journal={Molecular and cellular endocrinology},
  year={2015},
  volume={408},
  pages={62-72}
}
High output of steroid hormone synthesis in steroidogenic cells of the adrenal cortex and the gonads requires the expression of the steroidogenic acute regulatory protein (StAR) that facilitates cholesterol mobilization to the mitochondrial inner membrane where the CYP11A1/P450scc enzyme complex converts the sterol to the first steroid. Earlier studies have shown that StAR is active while pausing on the cytosolic face of the outer mitochondrial membrane while subsequent import of the protein… CONTINUE READING