Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling.

@article{Kim2008TranscriptionalAO,
  title={Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling.},
  author={Eun-jin Kim and Young-Gun Yoo and Woo-Kyeom Yang and Young-Soun Lim and Tae-Young Na and In-kyu Lee and M H Lee},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2008},
  volume={28 10},
  pages={1796-802}
}
OBJECTIVE Hypoxia-inducible factor 1alpha (HIF-1alpha) is primarily involved in the adapting of cells to changes in oxygen levels, which is essential for normal vascular function. Recently, physiological roles for retinoic acid-related orphan receptor alpha (RORalpha) have been implicated in cardiovascular diseases such as atherosclerosis. In this study, we have investigated the potential roles of RORalpha in the hypoxia signaling pathway in connection with activation of HIF-1alpha. METHODS… CONTINUE READING

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