Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA

Abstract

Mitochondrial transcription factor A (mtTFA/TFAM) is a nucleus-encoded, high-mobility-group-box (HMG-box) protein that regulates transcription of the mitochondrial genome by specifically recognizing light-strand and heavy-strand promoters (LSP, HSP1). TFAM also binds mitochondrial DNA in a non-sequence specific (NSS) fashion and facilitates its packaging… (More)
DOI: 10.1093/nar/gkr787

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Cite this paper

@inproceedings{Malarkey2012TranscriptionalAB, title={Transcriptional activation by mitochondrial transcription factor A involves preferential distortion of promoter DNA}, author={Christopher Malarkey and Megan L Bestwick and Jane E. Kuhlwilm and Gerald S. Shadel and Mair E. A. Churchill}, booktitle={Nucleic acids research}, year={2012} }