Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl-CoA derivative.

Abstract

Most peroxisomal proliferators consist of a carboxylic group attached to a hydrophobic backbone yielding an amphipathic carboxylate molecule. The respective CoA derivatives of peroxisomal proliferators, formed by ATP-dependent CoA thioesterification catalyzed by long-chain-acyl-CoA synthase, have been repeatedly considered as the immediate inducers of… (More)

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Cite this paper

@article{Hertz1994TranscriptionalAB, title={Transcriptional activation by amphipathic carboxylic peroxisomal proliferators is induced by the free acid rather than the acyl-CoA derivative.}, author={Rivi Hertz and Irwin R Berman and Jacob Bar-Tana}, journal={European journal of biochemistry}, year={1994}, volume={221 1}, pages={611-5} }