Transcriptional activation by NF-kappaB requires multiple coactivators.

  title={Transcriptional activation by NF-kappaB requires multiple coactivators.},
  author={Kelvyn Sheppard and Dave W Rose and Zaffar K. Haque and Riki Kurokawa and Eileen M. McInerney and Stefan K Westin and Dimitris Thanos and Michael G. Rosenfeld and Christopher K. Glass and Tucker Collins},
  journal={Molecular and cellular biology},
  volume={19 9},
Nuclear factor-kappaB (NF-kappaB) plays a role in the transcriptional regulation of genes involved in inflammation and cell survival. In this report we demonstrate that NF-kappaB recruits a coactivator complex that has striking similarities to that recruited by nuclear receptors. Inactivation of either cyclic AMP response element binding protein (CREB)-binding protein (CBP), members of the p160 family of coactivators, or the CBP-associated factor (p/CAF) by nuclear antibody microinjection… CONTINUE READING


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