Transcriptional Rewiring of Fungal Galactose-Metabolism Circuitry

  title={Transcriptional Rewiring of Fungal Galactose-Metabolism Circuitry},
  author={Mikhail Martchenko and Anastasia Levitin and Herv{\'e} Hogues and Andr{\'e} M. Nantel and Malcolm Whiteway},
  journal={Current Biology},
BACKGROUND The Leloir-pathway genes encode the enzymatic machinery involved in the metabolism of galactose. RESULTS In the distantly related fungi Saccharomyces cerevisiae and Candida albicans, the genes encoding these enzymes are syntenically arranged, but the upstream regulatory regions are highly divergent. In S. cerevisiae, the Leloir-pathway genes are positively regulated by Gal4p acting through the UAS(G) sequence CGG(N(11))CCG. However, in C. albicans, the Gal4p and UAS(G) combination… CONTINUE READING

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