Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems

@inproceedings{Liu2018TranscriptionalRR,
  title={Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems},
  author={Zhichao Liu and Brian Delavan and Ruth A Roberts and Weida Tong},
  booktitle={Front. Genet.},
  year={2018}
}
Toxicogenomics (TGx) is an important tool to gain an enhanced understanding of toxicity at the molecular level. Previously, we developed a pair ranking (PRank) method to assess in vitro to in vivo extrapolation (IVIVE) using toxicogenomic datasets from the Open Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System (TG-GATEs) database. With this method, we investiagted three important questions that were not addressed in our previous study: (1) is a 1-day in vivo short-term assay… CONTINUE READING
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