Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression

@inproceedings{Kluever2011TranscriptionalRO,
  title={Transcriptional Response of Zebrafish Embryos Exposed to Neurotoxic Compounds Reveals a Muscle Activity Dependent hspb11 Expression},
  author={Nils Kluever and Lixin Yang and Wibke Busch and Katja Scheffler and Patrick Renner and Uwe Str{\"a}hle and Stefan Scholz},
  booktitle={PloS one},
  year={2011}
}
Acetylcholinesterase (AChE) inhibitors are widely used as pesticides and drugs. Their primary effect is the overstimulation of cholinergic receptors which results in an improper muscular function. During vertebrate embryonic development nerve activity and intracellular downstream events are critical for the regulation of muscle fiber formation. Whether AChE inhibitors and related neurotoxic compounds also provoke specific changes in gene transcription patterns during vertebrate development that… CONTINUE READING
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