Transcriptional Repression of O-Methylguanine DNA Methyltransferase Gene Rendering Cells Hypersensitive to N,N -Bis(2-chloroethyl)-N-nitrosurea in Camptothecin-Resistant Cells


O-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that removes alkyl-adducts from the O-guanine in DNA and is a crucial defense against O-alkylating agentinduced cytotoxicity. We demonstrated here that two camptothecin (CPT)-resistant cell lines (CPT30 and KB100) were more sensitive to N,N -bis(2-chloroethyl)-N-nitrosurea (BCNU) than… (More)


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