Transcriptional Regulatory Networks in Saccharomyces cerevisiae

@article{Lee2002TranscriptionalRN,
  title={Transcriptional Regulatory Networks in Saccharomyces cerevisiae},
  author={Tong Ihn Lee and Nicola J. Rinaldi and François Robert and Duncan T. Odom and Ziv Bar-Joseph and Georg K. Gerber and Nancy M. Hannett and Christopher T. Harbison and Craig M. Thompson and Itamar Simon and Julia Zeitlinger and Ezra G. Jennings and Heather L. Murray and David Benjamin Gordon and Bing Ren and John J. Wyrick and Jean-Bosco Tagne and Thomas L. Volkert and Ernest Fraenkel and David Kenneth Gifford and Richard A. Young},
  journal={Science},
  year={2002},
  volume={298},
  pages={799 - 804}
}
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest… 
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