Transcriptional Regulation of an Evolutionary Conserved Intergenic Region of CDT2-INTS7

@article{Nakagawa2008TranscriptionalRO,
  title={Transcriptional Regulation of an Evolutionary Conserved Intergenic Region of CDT2-INTS7},
  author={Hiroki Nakagawa and Moe Tategu and Rieko Yamauchi and Kaori Sasaki and Sota Sekimachi and Kenichi Yoshida},
  journal={PLoS ONE},
  year={2008},
  volume={3}
}
Background In the mammalian genome, a substantial number of gene pairs (approximately 10%) are arranged head-to-head on opposite strands within 1,000 base pairs, and separated by a bidirectional promoter(s) that generally drives the co-expression of both genes and results in functional coupling. The significance of unique genomic configuration remains elusive. Methodology/Principal Findings Here we report on the identification of an intergenic region of non-homologous genes, CDT2, a regulator… 

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