Transcriptional Regulation of Mouse PXR Gene: An Interplay of Transregulatory Factors

  title={Transcriptional Regulation of Mouse PXR Gene: An Interplay of Transregulatory Factors},
  author={Sangeeta Kumari and Gauranga Mukhopadhyay and Rakesh Kumar Tyagi},
  booktitle={PloS one},
Pregnane X Receptor (PXR) is an important ligand-activated nuclear receptor functioning as a 'master regulator' of expression of phase I, phase II drug metabolizing enzymes, and members of the drug transporters. PXR is primarily expressed in hepatic tissues and to lesser extent in other non-hepatic tissues both in human and in mice. Although its expression profile is well studied but little is known about the regulatory mechanisms that govern PXR gene expression in these cells. In the present… CONTINUE READING


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