Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15*

@article{Mirghomizadeh2009TranscriptionalRO,
  title={Transcriptional Regulation of Mouse Mast Cell Protease-2 by Interleukin-15*},
  author={F. Mirghomizadeh and J. Bullwinkel and Z. Orinska and O. Janssen and A. Petersen and Prim B. Singh and S. Bulfone-Paus},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={32635 - 32641}
}
Mast cells (MCs) play a critical role in innate and adaptive immunity through the release of cytokines, chemokines, lipid mediators, biogenic amines, and proteases. We recently showed that the activities of MC proteases are transcriptionally regulated by intracellularly retained interleukin-15 (IL-15), and we provided evidence that this cytokine acts as a specific regulator of mouse mast cell protease-2 (mMCP-2). Here, we show that in wild-type bone marrow-derived mast cells (BMMCs) IL-15… Expand
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