Transcriptional Regulation by Nrf2

  title={Transcriptional Regulation by Nrf2},
  author={Claudia Tonelli and Iok In Christine Chio and David A Tuveson},
  booktitle={Antioxidants & redox signaling},
SIGNIFICANCE Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health. Recent Advances: Nrf2 regulates the transcription of components of the glutathione and thioredoxin antioxidant systems, as well as enzymes involved in phase I and phase II detoxification of exogenous and… CONTINUE READING
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