Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine

  title={Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine},
  author={Yuan-Hung Lo and Eunah Chung and Zhaohui Li and Ying-wooi Wan and Maxime M Mahe and Min-shan Chen and Taeko K. Noah and Kristin N. Bell and Hari Krishna Yalamanchili and Tiemo J Klisch and Zhandong Liu and Joo-Seop Park and Noah F Shroyer},
  booktitle={Cellular and molecular gastroenterology and hepatology},
BACKGROUND & AIMS The transcription factor atonal homolog 1 (ATOH1) controls the fate of intestinal progenitors downstream of the Notch signaling pathway. Intestinal progenitors that escape Notch activation express high levels of ATOH1 and commit to a secretory lineage fate, implicating ATOH1 as a gatekeeper for differentiation of intestinal epithelial cells. Although some transcription factors downstream of ATOH1, such as SPDEF, have been identified to specify differentiation and maturation of… CONTINUE READING
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