Transcriptional Pre-patterning of Drosophila Gastrulation

  title={Transcriptional Pre-patterning of Drosophila Gastrulation},
  author={Bomyi Lim and Michael Levine and Yuji Yamazaki},
  journal={Current Biology},
Gastrulation of the Drosophila embryo is one of the most intensively studied morphogenetic processes in animal development [1-4]. Particular efforts have focused on the formation of the ventral furrow, whereby ∼1,000 presumptive mesoderm cells exhibit coordinated apical constrictions that mediate invagination [5, 6]. Apical constriction depends on a Rho GTPase signaling pathway (T48/Fog) that is deployed by the developmental regulatory genes twist and snail [7-10]. It is thought that coordinate… CONTINUE READING