Transcriptional Network Inference and Master Regulator Analysis of the Response to Ribosome-Inactivating Proteins in Leukemia Cells.

  title={Transcriptional Network Inference and Master Regulator Analysis of the Response to Ribosome-Inactivating Proteins in Leukemia Cells.},
  author={Daniele Mercatelli and Massimo Bortolotti and Federico Manuel Giorgi},
The Transcriptome of SH-SY5Y at Single-Cell Resolution: A CITE-Seq Data Analysis Workflow
An ideal CITE-seq data analysis workflow is illustrated by characterizing the transcriptome of SH-SY5Y neuroblastoma cell line, a widely used model to study neuronal function and differentiation, and how to use some popular R packages to investigate cell heterogeneity in scRNA- sequencing data.
Therapeutic Uses of Bacterial Subunit Toxins
It is clear that Gb3 (and VT targeting) is upregulated in many human cancers and that there is a relationship between GSL expression and cancer drug resistance, as well as the interaction of cholera AB5 toxin with its GSL receptor, GM1 ganglioside.
The Transcriptome of SH ‐ SY 5 Y at Single ‐ Cell Resolution :
  • 2021
Detection of subtype-specific breast cancer surface protein biomarkers via a novel transcriptomics approach
BRCA patients can be stratified into five surface activity-specific groups having the potential to identify subtype-specific actionable targets to design tailored targeted therapies or for diagnostic purposes.


Gene regulatory network inference resources: A practical overview.
Global Transcriptional Response of Macrophage-Like THP-1 Cells to Shiga Toxin Type 1
Comparative microarray analyses to characterize the global transcriptional response of human macrophage-like THP-1 cells to Shiga toxin type 1 (Stx1) and lipopolysaccharides suggest mechanisms to dampen the Macrophage proinflammatory response may be built into host response to the toxins.
Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
Human Kruppel-like factor 2 (KLF2) is a Cys2/His2 zinc-finger-containing transcriptional factor, which is involved in multiple cellular pathways and inhibits WEE1 transcription, and enhanced KLF2 expression sensitizes cells to DNA damage-induced apoptosis.
Direct Activation of Ribosome-Associated Double-Stranded RNA-Dependent Protein Kinase (PKR) by Deoxynivalenol, Anisomycin and Ricin: A New Model for Ribotoxic Stress Response Induction
Findings are consistent with a sentinel model whereby multiple PKR molecules basally associate with the ribosome positioning them to respond to ribotoxin-induced alterations in rRNA structure by dimerizing, autoactivating and, ultimately, evoking RSR.
Activation of cell stress response pathways by Shiga toxins
The characterization of stress responses activated by Shiga toxin‐producing bacteria may identify targets for the development of interventional therapies to block cell damage and disease progression.
Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling
The early response to stenodactylin treatment involves inflammatory and apoptotic signaling compatible with the activation of multiple cell death pathwayscompatible with theactivation of multiplecell death pathways.
VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer
It is demonstrated that GRHL2 is recruited to a subset of estrogen receptorbinding sites and regulates transcriptional output, as evidenced by changes in estrogen receptor-associated eRNA expression and stronger estrogen receptor binding at active enhancers after GRHL 2 knockdown.
Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways
It is concluded that α-MMC stimulates inflammatory responses in human monocytes by activating of IKK/NF-κB and JNK pathways, raising the possibility that consumption of α- MMC-containing food may lead to inflammatory-related diseases.