Transcriptional Network Inference and Master Regulator Analysis of the Response to Ribosome-Inactivating Proteins in Leukemia Cells.

  title={Transcriptional Network Inference and Master Regulator Analysis of the Response to Ribosome-Inactivating Proteins in Leukemia Cells.},
  author={Daniele Mercatelli and Massimo Bortolotti and Federico Manuel Giorgi},

Detection of pan-cancer surface protein biomarkers via a network-based approach on transcriptomics data.

The ability of SURFACER to discover relevant knowledge within and across cancer datasets is shown and it is shown how different cancers can be stratified in surface-activity-specific groups.

Detection of subtype-specific breast cancer surface protein biomarkers via a novel transcriptomics approach

BRCA patients can be stratified into five surface activity-specific groups having the potential to identify subtype-specific actionable targets to design tailored targeted therapies or for diagnostic purposes.

The Transcriptome of SH-SY5Y at Single-Cell Resolution: A CITE-Seq Data Analysis Workflow

An ideal CITE-seq data analysis workflow is illustrated by characterizing the transcriptome of SH-SY5Y neuroblastoma cell line, a widely used model to study neuronal function and differentiation, and how to use some popular R packages to investigate cell heterogeneity in scRNA- sequencing data.

Therapeutic Uses of Bacterial Subunit Toxins

It is clear that Gb3 (and VT targeting) is upregulated in many human cancers and that there is a relationship between GSL expression and cancer drug resistance, as well as the interaction of cholera AB5 toxin with its GSL receptor, GM1 ganglioside.

The Transcriptome of SH ‐ SY 5 Y at Single ‐ Cell Resolution :

  • 2021



Gene regulatory network inference resources: A practical overview.

Global Transcriptional Response of Macrophage-Like THP-1 Cells to Shiga Toxin Type 1

Comparative microarray analyses to characterize the global transcriptional response of human macrophage-like THP-1 cells to Shiga toxin type 1 (Stx1) and lipopolysaccharides suggest mechanisms to dampen the Macrophage proinflammatory response may be built into host response to the toxins.

Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis

Human Kruppel-like factor 2 (KLF2) is a Cys2/His2 zinc-finger-containing transcriptional factor, which is involved in multiple cellular pathways and inhibits WEE1 transcription, and enhanced KLF2 expression sensitizes cells to DNA damage-induced apoptosis.

Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling

The early response to stenodactylin treatment involves inflammatory and apoptotic signaling compatible with the activation of multiple cell death pathwayscompatible with theactivation of multiplecell death pathways.

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

It is demonstrated that GRHL2 is recruited to a subset of estrogen receptorbinding sites and regulates transcriptional output, as evidenced by changes in estrogen receptor-associated eRNA expression and stronger estrogen receptor binding at active enhancers after GRHL 2 knockdown.

Ribosome-Inactivating Protein α-Momorcharin Derived from Edible Plant Momordica charantia Induces Inflammatory Responses by Activating the NF-kappaB and JNK Pathways

It is concluded that α-MMC stimulates inflammatory responses in human monocytes by activating of IKK/NF-κB and JNK pathways, raising the possibility that consumption of α- MMC-containing food may lead to inflammatory-related diseases.

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB

Ribosome-Inactivating Proteins from Plants: A Historical Overview

The biological properties of these proteins, including their abortifacient, anticancer, antiviral and neurotoxic activities, suggest that RIPs could be utilized in agriculture and in many biomedical fields, including clinical drug development.

Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent

Gen ontology analysis indicated that pathways impacted by Onconase include MAPK signaling, cytokine-cytokine-receptor interactions, and Jak-STAT signaling, and contribute to the overall understanding of MM cell response to OnConase as a therapeutic strategy.